For example, in STAMPEDE trial 51% and 31% of assessable patients in ADT+D and ADT alone arms respectively experienced ≥ grade III adverse events. Comprehensive meta-analysis version 3.0 was used to perform the ADM. The primary endpoint of interest was overall survival (OS). Results: The trials included a total 2,261 patients with M1 disease. Three RCTs fulfilled the inclusion criteria and were then subjected to meta-analysis.[8-10] The trials included a total of 2,951 patients.
This strategy should be discussed with patients who can tolerate chemotherapy. This meta-analysis is a statistical systemic review of results of published trials. Eur Urol 2016;70:256-62. 13. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Their final recommendations were recently published and they reflect the differences in opinions. Two thousand two hundred and sixty-one patients were eligible for the meta-analysis after eliminating 690 patients with advanced but non-metastatic disease in one of the 3 trials. One thousand three hundred and ten patients were in ADT arms and 951 in ADT+D arms. Any future IPD meta-analysis will very likely concentrate on metastatic disease volume subgroups analysis. A panel of 41 prostate cancer experts from 17 countries identified the management of hormone naïve metastatic prostate cancer as one of the controversial subjects.
Acknowledgments Special thanks to Rawan AlSaadi (B.SC) for statistical analysis. Patients with non-metastatic disease (M0) were eligible if they had 2 or more of the following criteria: stage T3/4, prostate specific antigen ≥ 40 and Gleason score 8-10. Twenty four percent and 17% of all patients recruited to the 6 arms of STAMPEDE trial had N0M0 and N+M0 stage respectively. Median follow up ranged between 29 and 50 months. The search covered the period from January 2004 until December 2015 (inclusive). Both authors reviewed the identified data and reached an agreement on the data to be included as per the above inclusion criteria. Three randomized trials reported the results of this approach.